Seahawks Lose Drake Thomas to Ankle Injury Against 49ers

Seattle Seahawks linebacker Drake Thomas suffered an ankle injury during the Week 5 matchup against the San Francisco 49ers, leaving the game with an uncertain return status as Seattle tried to recover against its NFC West rival, according to CBS Sports and Field Gulls.

Thomas was listed as questionable to return after the injury occurred in the first half, CBS Sports reported. The Seahawks defense adjusted by replacing him with Tyrice Knight while evaluating its linebacker options.

Field Gulls reported that Thomas was injured late in the second quarter while defending a 49ers passing play. Knight and Patrick O’Connell became candidates for expanded roles at inside linebacker after Thomas left the contest.

The fourth-year Seahawks linebacker had become a key defensive contributor alongside Ernest Jones IV, according to Field Gulls. The report noted Thomas recorded 18 tackles during the 2026 season and made his second career interception in the previous week.

Seattle entered the second half trailing San Francisco 21-13 after three turnovers allowed the 49ers to score 21 points, according to Field Gulls. The team needed its remaining linebackers to maintain defensive production while Thomas’ availability remained uncertain.