Jaguars Lose Anton Harrison to Leg Injury Against Eagles in London

The Jacksonville Jaguars lost starting left tackle Anton Harrison to an apparent leg injury during their Week 5 matchup against the Philadelphia Eagles at Tottenham Hotspur Stadium in London on October 11, 2026. Harrison went down in the third quarter while attempting to block Philadelphia defensive lineman Moro Ojomo and was taken off the field on a cart.

According to NBC Sports, Harrison suffered a non-contact injury and rode the cart to the locker room. His departure left Jacksonville without its regular starter at left tackle as the team struggled to protect its offense against Philadelphia's defensive front.

The Jaguars inserted Walker Little, a former starting left tackle, to replace Harrison. Jacksonville also had Cole Van Lanen available as a potential option on the left side, where he finished the 2025 season, according to The Florida Times-Union's Jacksonville.com.

Harrison's injury came amid a difficult stretch for Jacksonville's offensive line. Before he left the game, the unit had committed three holding penalties, while Harrison had also been flagged for a false start.

Two plays after Harrison's departure, rookie guard Emmanuel Pregnon received his third holding penalty of the game. The Jaguars were having difficulty containing Philadelphia defensive linemen Jalen Carter and Jordan Davis, according to Jacksonville.com.

Harrison had established a record of durability since entering the NFL in 2023. According to Jacksonville.com, he had missed only three of 56 games since his rookie season before the latest injury.

The extent of Harrison's injury was not confirmed in the source reports. NBC Sports indicated that his day was likely over, while Little took over at left tackle for the remainder of the immediate action.