Eagles and Jaguars Reveal Week 5 Inactive Players in London

Philadelphia will face Jacksonville in their Week 5 NFL matchup in London with significant changes to the Eagles' lineup, as several players are unavailable because of injuries or other roster circumstances. The Jaguars enter the game with fewer absences, while Philadelphia must adjust its offensive and defensive personnel.

According to the inactive lists published ahead of the matchup, the Eagles will be without running back Saquon Barkley, wide receiver DeVonta Smith, center Drew Kendall, edge defender Jonathan Greenard, safety Marcus Epps and wide receiver Hollywood Brown. Their absences create opportunities for other players to take on larger roles.

Barkley's absence is particularly significant because Tank Bigsby is also on injured reserve. Philadelphia plans to start Will Shipley at running back, added Dameon Pierce to its 53-man roster and elevated Carson Steele from the practice squad for the game.

With Smith unavailable, tight end Dallas Goedert is expected to become quarterback Jalen Hurts' primary passing target. The absence of Brown also leaves Philadelphia with fewer options to provide speed at wide receiver.

Greenard did not practice during the week and had been listed as questionable before being ruled out. At safety, Michael Carter is set to start in place of Epps.

The Eagles' offensive line has also undergone significant changes. Left guard Landon Dickerson remains on injured reserve but is eligible to return after Week 5, while Drew Kendall had been filling in at center and Cam Jurgens had moved to left guard before being traded to the Baltimore Ravens.

Dickerson was placed on injured reserve after Philadelphia's Week 1 victory over the Washington Commanders. Jurgens' departure leaves the team needing to manage its offensive line personnel while dealing with additional absences.

Bigsby suffered an injury during the Week 4 game against the Los Angeles Rams that required core muscle surgery. He is expected to return this season, although his recovery could keep him out for roughly two months and he is eligible to return after Week 8.

Tight end Eli Stowers, whom Philadelphia selected in the second round of the 2026 NFL Draft, is also on injured reserve. He was listed as questionable with a hamstring injury before Week 1 and subsequently moved to injured reserve. Although he is now eligible to return, he has not yet been activated.

Jacksonville's inactive list includes starting right guard Patrick Mekari, safety Caleb Ransaw and defensive lineman B.J. Green. All three are on injured reserve, according to the team's roster information.

Mekari underwent back surgery in August, leaving Ezra Cleveland to fill in at right guard. Ransaw, the Jaguars' third safety, injured his knee during Week 4. Green served as a rotational defensive lineman and recorded 15 tackles and two sacks last season.