Deebo Samuel Leaves 49ers Seahawks Game With Hamstring Injury

San Francisco 49ers wide receiver Deebo Samuel suffered a hamstring injury and left the Week 5 game against the Seattle Seahawks on October 11, 2026, at Lumen Field in Seattle after a third quarter rushing attempt forced him out.

According to uk.sports.yahoo.com, Samuel was injured on a first and 10 carry off left tackle late in the third quarter. He received medical attention before moving to the sideline and was ruled out for the rest of the contest.

Samuel finished the game with two receptions for 21 yards and two rushing attempts for four yards, according to joxfm.com. He entered the matchup with 14 receptions for 185 yards and three touchdowns this season.

The injury came after Samuel lost a fumble on the rushing play, giving Seattle possession at San Francisco's 36 yard line, according to joxfm.com. Seattle responded with Jason Myers making a 48 yard field goal to give the Seahawks a 26 21 lead.

The 49ers also faced additional uncertainty at wide receiver during the game. Niners Wire reported that Jacob Cowing suffered an ankle injury on a kickoff return and was initially listed as questionable to return before coming back in the fourth quarter.

San Francisco entered the game already dealing with major absences at receiver. According to Niners Wire, Ricky Pearsall, Christian Kirk, De'Zhaun Stribling and Demarcus Robinson had all been placed on injured reserve.

With Samuel unavailable, Jordan Watkins was listed as his backup on the 49ers depth chart, according to uk.sports.yahoo.com. The 2025 fourth round draft pick entered the game with four career catches for 86 yards in six appearances.

Uk.sports.yahoo.com reported that the 49ers dressed five wide receivers for the matchup: Mike Evans, Deebo Samuel, Jacob Cowing, Jordan Watkins and Brandin Cooks. Samuel's exit left San Francisco with fewer healthy options for the remainder of the game.