Deebo Samuel Exits 49ers Game With Hamstring Injury

San Francisco 49ers wide receiver Deebo Samuel was ruled out of the team's game against the Seattle Seahawks on Sunday, Oct. 11, 2026, in Seattle, after sustaining a hamstring injury late in the third quarter. His departure followed a fumble that gave Seattle possession and set up a scoring drive. According to the Associated Press, Samuel lost the ball at the 49ers' 35-yard line and remained motionless on the field for several seconds before limping toward the sideline.

The team subsequently ruled him out for the remainder of the game. Seahawks cornerback Josh Jobe recovered the fumble. Seattle converted the turnover into points, kicking a field goal four plays later to increase its lead to 26-21, according to the Associated Press.

Samuel recorded two receptions for 21 yards and two rushing attempts for 4 yards before leaving the contest. His departure ended his participation in the game with four total touches and 25 combined yards from scrimmage.

The game also featured seven combined turnovers through three quarters, according to the Associated Press. Samuel's fumble was one of the turnovers during a contest in which possession changed hands repeatedly. The injury forced San Francisco to continue without Samuel for the remainder of its matchup with Seattle. The available report did not provide a further diagnosis, an estimated recovery timeline or additional details about the severity of his hamstring injury.