49ers Face Seahawks With Mykel Williams Back for Week 5

San Francisco began its Week 5 road matchup against the Seattle Seahawks on October 11, 2026, with an undefeated 4-0 record and several important roster changes. The 49ers activated defensive end Mykel Williams after his recovery from a torn ACL, made rookie cornerback Ephesians Prysock available for his NFL debut, and prepared to face the defending Super Bowl champions despite several key absences.

According to reports from Yahoo Sports and Niners Nation, Williams returned to the lineup after being sidelined by his knee injury, strengthening a defensive front that also included Keion White, Romello Height, Khalid Kareem, and Ogbo Okoronkwo. The team had signed Okoronkwo to its practice squad on October 10, following his appearance in four games this season, including one start, with two tackles and 1.0 sack.

Prysock became available for the first time in his NFL career as San Francisco managed limited depth at safety. Niners Nation reported that his initial contribution was expected to come primarily on special teams, while Upton Stout was also active after dealing with a shoulder injury.

George Kittle was available despite battling an illness throughout the week, according to Yahoo Sports. Wide receivers Mike Evans, Deebo Samuel, Jordan Watkins, Jacob Cowing, and Brandin Cooks were also available, giving quarterback Brock Purdy several receiving options for the divisional contest.

Christian McCaffrey, Kaelon Black, and Jordan James were listed among the available running backs. Tight ends Luke Farrell, Brayden Willis, and Jack Stoll were also available, providing additional options with fullback Kyle Juszczyk sidelined by a knee injury.

San Francisco entered the game without several players, including defensive end Nick Bosa, who was out with a knee injury, and safety Marques Sigle, who was dealing with an ankle injury. Defensive tackle James Thompson Jr. was inactive with an ankle injury, while offensive tackle Enrique Cruz Jr. was also inactive. Linebacker Tatum Bethune was unavailable as well, according to Yahoo Sports.

The matchup marked another test for a 49ers team that had opened the season with four consecutive victories. San Francisco's early wins included victories over the Los Angeles Rams and Denver Broncos, with the latter ending 24-14, according to Niners Nation and Yahoo Sports.

Seattle entered Week 5 with a 3-1 record, according to Niners Nation's schedule review. The Seahawks had lost 33-31 on the road to the Washington Commanders, their only defeat through four games, while continuing to adjust their rushing attack following Kenneth Walker III's departure in free agency.

The 49ers' upcoming schedule also included a Week 6 home game against Washington, a Week 7 road trip to face the Atlanta Falcons, and a Week 8 bye before hosting the Las Vegas Raiders in Week 9. Atlanta held a 2-2 record entering the period, while Las Vegas had started 3-0 before losing a close Week 4 game to the Kansas City Chiefs.